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Advantages:
1. In general, a major advantage of dry granules over wet granules is the absence of water or any organic solvents. Therefore, this method is particularly attractive for drugs, which are sensitive to moisture or heat.
2. It is suitable for compounds that either have low melting points or decompose rapidly on heating, as the method involves no drying step.
3. Roll compaction results in the formation of granules that create porous tablets that allow water to penetrate the tablet more easily. This leads to improved disintegration behavior of the tablet.
4. In addition, this process is environmentally friendly. Also the roll compaction technique provides an efficient and easily automated process
5. Low operational costs.
6. Dust problems are reduced or avoided and die filling is improved during tableting.
7. The capping of the tablet can also be reduced.
8. Roll compaction/dry granulation may be used, if the drug or excipient flows poorly or is sensitive to heat or moisture.
9. It can also be used for powder concentration prior to encapsulation.
Disadvantages:
1. One of the disadvantages of roll compaction is a phenomenon called ‘loss of recyclability’. Tablets prepared by roll compaction often show lower tensile strength than tablets prepared by wet granulation or direct compaction. A minimum compaction force should be used, as well as a small particle size of the starting powder.
2. A second disadvantage of roll compaction is the production of non-compacted powder. Since no liquid binder is used, a higher amount of fines remains and a lower product yield is obtained as opposed to wet granulation.
