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Wet granulation is a sizing process in which a liquid is added to a powder to form agglomeration or granules. It is the oldest and most common method of tablet production. It is also the method of choice when large doses of medication are being tapered.
Wet granules are prepared using oscillating granulators, high-speed mixers/granulators, fluid-bed granulators or even extruders and spheronizers. The wet granules are properly dried and mixed with other necessary ingredients and finally compressed into tablets using a tablet press.
Granulation is a unit operation in which small powder particles aggregate to form aggregates called granules. To achieve cohesion between the powders, it is necessary to include adhesive substances called binders or granulating agents in the formulation. It is a common practice to use granulation solution as it is more effective compared to the same amount of dry powder binder. Powder mixing, together with the cohesive properties of the binder, enables the formation of granules which, when properly compressed using a tablet press, produce tablets with desired properties.
The wet granulation method is a size-enhancing process in which fine powder particles are agglomerated or aggregated into larger, stronger and relatively permanent structures called granulators using a suitable non-toxic granulating liquid such as water, isopropanol or ethanol (or mixtures thereof). . The granulating fluid can be used alone or as a solvent containing a binder or granulating agent. The choice of granulating fluid depends greatly on the properties of the material to be granulated. Powder mixing, together with the cohesive properties of the granulating agent, enables granulation. The properties and performance of the final product depend on the extent to which the powder particles interact with each other to form aggregates (granules).
