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Cause of tablet Defects
Tablet defects can occur in a variety of ways, but the most common culprits are improper manufacturing processes or defective raw materials. Here are five of the most common causes of tablet failure.
1. Inadequate tablet compression
One of the key steps in tablet manufacturing is to accurately compress the powder tablets into a solid form. If this step is not performed correctly, the tablets will be too soft and will likely break during shipping or use.
2. Incorrect tablet shape
Another common cause of tablet failure is incorrect tablet shape. Sometimes, tablets are too round or too oblong, which makes them difficult to ship and use.
3. Insufficient tablet coating
The outer layer of a tablet is usually made of two types of materials: a drug substance and an inert carrier. The drug substance is what goes inside the patient’s body and needs to be protected from environmental damage, while the inert carrier helps keep everything together and provides a smooth surface for patients to swallow.
4. Substandard drug substance
One of the biggest challenges for pharmaceutical manufacturers is finding high-quality drug substances that meet all the required properties. If one of these substances is defective, it may impair the quality of the tablet.
5. Defective tablet manufacturing process
Other common causes of tablet defects include faulty manufacturing processes, such as air bubbles or heat damage. If any of these problems occur during tablet production, it can cause defects in the finished product.
Solution to tablet Defects
The tablet manufacturing process is a complex and delicate process that must be followed carefully to ensure a quality product. Unfortunately, even the best-managed processes can lead to tablet malfunctions.
Related: Tablet error pdf
Defects can occur at any stage of the manufacturing process, but they are particularly common at the tablet-finishing stage. Here are some solutions to help reduce the impact of tablet errors:
1. Use quality raw materials: The quality of a tablet’s ingredients is critical to its success. Make sure your materials are of high quality and consistent in composition. This will help ensure that your tablets meet your product specifications and are free of defects.
2. Follow Good Manufacturing Practices: Adhering to Good Manufacturing Practices (GMPs) will help prevent defects from occurring. These guidelines include ensuring that processes are properly controlled and supervised, reliable equipment is used, and products are tested for accuracy before they are released to the market.
3. Use automated systems: Automated systems can help reduce the amount of human error that can lead to errors. They can also streamline the manufacturing process, which can save time and money.
4. Use quality control measures: Quality control measures such as inspection and testing can help detect and correct any defects before they affect the quality of the final product.
By following these tips, you can help reduce the impact of tablet defects in your pharmaceutical manufacturing process
