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The importance of lubricants in tablet formulation cannot be denied. They are essential for controlling material flow, preventing clogging and reducing friction during tablet compression. Additionally, lubricants can provide various other benefits such as product stability and improved release properties.
Lubricants are often used in combination with other tableting additives to achieve the desired results. For example, talc is often used as a lubricant and binder in low-dose chewable tablets. This combination helps reduce friction and ensure a smooth tablet mouthfeel. Other additives that may be used in conjunction with lubricants include fillers (such as microcrystalline cellulose), disintegrants (such as croscarmellose sodium), and wetting agents (such as sodium lauryl sulfate).
Ultimately, the choice of lubricant will depend on the specific application scenario. However, there are some general principles that should always be considered when selecting a lubricant: viscosity, compatibility with other components and toxicity.
