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a. Ease of swallowing
b. Dosage accuracy/uniformity: Precise fill volume of liquid fill unit delivers a greater degree of accuracy and consistency from capsuleto-capsule and lot-to-lot.
c. Consistent manufacturing requirements: More accurate compounding, blending, and dispensing of liquid fill facilitates manufacturing. Liquid blends are more homogeneous.
d. Increase in bioavailability: Absorption and bioavailability can be enhanced by formulating compounds in solution including solubilizers and absorption enhancers, if necessary. Water-insoluble drugs may be formulated in a softgel. Clinical studies have shown enhanced absorption and bioavailability with softgel forms. Examples are temazepam (Salonen et al., 1986) and ibuprofen (Saano et al., 1991).
e. Enhanced stability and security: The tight hermetical sealing protects fill from air and environmental contamination. Gelatin shell can be formulated to block out ultraviolet light. Streamlined, onepiece design is tamper-evident.
f. Pliable shell: soft gel shell allows for custom shapes and sizes appropriate for oral, topical, chewable and suppository delivery.
g. Portability: Encapsulated liquid dosage formulations become highly portable for consumers/patients
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