Microbiological contamination control is the process of preventing the introduction of infectious materials like bacteria, yeast, mold, fungi, viruses, prions, and protozoa.
The three standard options for contamination control are prevention, cleaning, and monitoring.
Reduce Contamination in a lab
▪️Wear ...
Contamination is a very serious issue in pharmaceutical manufacturing especially in sterile manufacturing. It is important to control the contamination in the pharmaceutical manufacturing area to protect the product. There are many ways of contamination so there are different strategies to control it. ...
For decades, non-functional particle cleaning levels have been closely measured and monitored in pharmaceutical cleanrooms, in an effort to improve drug quality and save patient lives. In parallel effective microbial contamination levels have also been closely measured and monitored through the use ...
Contamination control for pharmaceutical manufacturing is an essential factor in the overall success of a pharmaceutical product. This article reviews some pollution control strategies for controlling microbial growth, including environmental control, worker protection, and medical waste management.
The ...
1. Cross contamination with active ingredients Contamination of one batch of product with significant levels of residual active ingredients from a previous batch cannot be tolerated. In addition to the obvious problems posed by subjecting consumers or patients to unintended contaminants, potential clinically ...
=>> Sample only one element at a time
=>> Sampling in a separate cubicle/booth fitted with suitable air control system.
=>> Use of dedicated tools for sampling
=>> Dispensing stations must be equipped with suitable dust extraction systems.
=>> All packaged containers must be effectively cleaned before ...
Follow a validated cleaning protocol with written SOPs
Choose and use qualified cleanroom wipes and other cleanroom cleaning supplies.
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• Clean rooms shall be designed and classified into different grades according to the type of activity performed.
• Clean rooms should be maintained with proper cleanliness standards and the supplied air should pass through a series of filters of proper efficiency.
• Cleanliness levels should be ...
1. Install dedicated HVAC systems with appropriate filters in all process areas.
2. Install suitable airlock with pressure differential.
3. Air intake should not be located near wet drains, air exhaust or dust sources.
4. Air supply and exhaust points should not be so close or so disposed that it restricts ...