The four main mechanisms of granule formation initially described by Ennis include: 1. Wetting and Nucleation This is the first and an important stage of granule formation. It involves the initial wetting of the powder bed and the nucleation of existing grains by the granulating liquid. This step is ...

Advantages of wet granulation 1. Wet granulation modifies the properties of formulation components to overcome their tableting deficiencies. The formed granules are relatively more spherical than the powder and have better flow properties. 2. The improved compressibility of the powders resulting from ...

Dry Mixing: Intra-granular ingredients with or without the API is intimately mixed in the bowl ofLSMG, HSMG or FBPD Wet granulation involves the massing of a mix of dry primary powder particles using agranulating fluid. The fluid contains a solvent which must be volatile so that it can be removedby drying, ...

Wet granulation is a sizing process in which a liquid is added to a powder to form agglomeration or granules. It is the oldest and most common method of tablet production. It is also the method of choice when large doses of medication are being tapered. Wet granules are prepared using oscillating granulators, ...