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Granules are formed by addition of granulating liquid onto a substrate in a mixing bowl of:(LSMG, HSMG or FBPD)
The substrate (intra-granular ingredient) may include the API and/or a binder: Mixed intensivelybefore addition of the granulating liquid to achieve uniformity.
Granulating liquid: Aqueous or Solvent with or without binder and may contain API in solution orin dispersion state.
While the mixing process is continued either in the bowl of High-Shear Mixer Granulator with animpeller and chopper mixing or in the Fluid Bed Processor Dryer the granulating liquid is addedat a constant rate until all is added
Further mixing is continued until pre-determined granulation end-point is reached (by measuringthe resistance/constrain on the impeller (ohms) or consumption of the electric energy (watts).
In the fluid bed processor both granulation and drying is achieved in a continuous process. Theend point is reached by achieving the desired LOD and product temperature.
