Laminar Air Flow (LAF)


A laminar air flow system is an important concept in controlling particulate pollution in a pharmaceutical industry. It provides an aseptic environment in specific areas to perform various operations during manufacturing. Cleanrooms in the pharmaceutical industry maintain particle-free air using HEPA or ULPA filters that employ laminar or turbulent air flow principles.

Laminar airflow is acting through air moving at the same speed and in the same direction, with no or minimal cross-over of airflow. Most pollution-sensitive environments in the pharmaceutical industry, such as dust-free hoods, require laminar flow because it predictably sweeps particles in a uniform direction from the cleanest area under the hood. This design ensures that the cleanest area will always be the closest upstream area of the hood. Laminar air flow systems are typically employed across 80% of a cleanroom ceiling to maintain constant air flow.

Laminar flow cabinets (tissue culture hoods) operate using in-flow laminar air drawn through one or more HEPA filters, designed to create a particle-free work environment and provide product protection. Air is taken through a filtration system and then exhausted across the work surface as part of the laminar flow process. A constant positive air pressure is maintained in the laminar flow cabinet to prevent infiltration of contaminated room air.

Laminar flow cabinets are ideal for general lab work, especially in the medical, pharmaceutical, electronic and industrial sectors. In a pharmaceutical industry, laminar flow cabinets are suitable for various applications and especially where a separate clean air environment is required for particle sensitive products. Due to its quality conforming to international standards, this cabinet is also widely used in various clean rooms and microbiological laboratories.

To make it highly valuable for safely placing various air points in clean room applications, some manufacturers emphasize its customized design.

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