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Dry syrup refers to medicines that are in powder form. The powder drug is dissolved in water to administer the dry syrup. This type of drug is best for treating children because of its relative ease of administration compared to other drugs. It provides a safe way to store drugs that are not stable in liquid form, especially antibiotics. Dry syrup helps avoid physical stability problems with normal suspensions. The formulation also reduces the weight of the drug which makes transportation cheaper.
While preparing the dry syrup medicine, the dry mixture should have a uniform concentration of the required ingredients. This ensures that the drug does not break up into a non-homogeneous mixture during reconstitution which can lead to dosing errors. Items used in the manufacture of dry syrups include excipients, granule disintegrates, granule binders and powder blends.
Excipients are used for stability of active ingredients for long periods of time. The type of excipient used is based on suitability for reconstitution and type of powder. Granule disintegrates help ensure that dry syrup particles do not aggregate during reconstitution. The granule binder helps ensure that the dry syrup particles remain in suspension.
The production of dry syrup begins with the preparation of the powder mixture. Ingredients used in production are weighed and distributed. The next step involves sieving the material. The dry syrup should have uniform granules so there may be several stages of straining to ensure a homogeneous powder. The powder is transferred to the drum mixer. Mixing of the dry mix is done in two steps to ensure complete mixing.
The first stage involves mixing the powder with a key excipient that helps disperse it. In the second stage, the remaining excipients are mixed. Powder and granular excipients are combined. At this stage, other heat sensitive auxiliaries such as flavors are added to the dry syrup mixture to avoid exposure to excess temperature.
Dry syrup is packaged using filling and sealing machines. The dry syrup is filled in suitable packaging and sealed. The container should have a wide mouth with enough air space for easy flow of liquid. The container should protect the contents from excessive heat, moisture and freezing. After packaging, the container is labeled and should include the “shake before use” label. This label ensures that the dry syrup has a homogeneous mixture before reconstitution.
Labels also include instructions for use and reconstitution. It also includes the conditions under which the reconstituted solution should be stored. Packing and cartoning is done automatically using packing and cartoning machines. Dry syrup should be stored at room temperature to preserve the active ingredients until use.
The dry syrup manufacturing process involves rigorous quality testing and assurance at various levels. Moisture levels and temperatures are tested during granulation and formulation to ensure drug safety and quality.
